Impact of Epicardial Adipose Tissue on Myocardial Function and Structure in Patients with sEvere Aortic Valve Stenosis
In patients with severe AS, increased EAT volume is independently associated with impaired LA function but not with other features of biventricular morphology, function or tissue composition. The incremental deterioration of LA function, in addition to the afterload imposed by AS in these patients, could increase vulnerability to heart failure and may require consideration as a therapeutic target beyond TAVR.
Authors
- Gerd Hasenfuß (ORCID: https://orcid.org/0000-0002-5942-361X)
- Bo Eric Beuthner
- Johannes T. Kowallick (ORCID: https://orcid.org/0000-0002-3580-619X)
- Sören J. Backhaus (ORCID: https://orcid.org/0000-0002-2683-6418)
- Alexander Schulz (ORCID: https://orcid.org/0000-0001-5589-8792)
- Judith Gronwald (ORCID: https://orcid.org/0009-0000-4953-1409)
- Torben Lange (ORCID: https://orcid.org/0000-0003-0505-2582)
- Andreas Schuster (ORCID: https://orcid.org/0000-0003-1508-1125)
- Karl Toischer (ORCID: https://orcid.org/0000-0002-9644-3716)
- Ruben Evertz (ORCID: https://orcid.org/0000-0002-5904-4652)
- Miriam Puls (ORCID: https://orcid.org/0000-0001-5540-1264)
Institutions
- Beth Israel Deaconess Medical Center (US)
- King's College London (GB)
- Justus-Liebig-Universität Gießen (DE)
- Global Climate Forum (DE)
- German Centre for Cardiovascular Research (DE)
- Kerckhoff Klinik (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1002/ehf2.15422
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00