A case report on IDH-mutant astrocytoma, CNS WHO grade 4: multi-omic characterization of untreated clinical progression
This case highlights the clonal progression of an IDH-mutant astrocytoma from grade 2 to grade 4, potentially driven by additional mutations and immune remodeling. These exploratory findings suggest candidate mechanisms of glioma evolution and may inform adoptive T-cell therapy approaches.
Authors
- Yajing Xu (ORCID: https://orcid.org/0000-0001-7747-7809)
- Wei Wei (ORCID: https://orcid.org/0000-0002-3117-9598)
- Fei Li (ORCID: https://orcid.org/0000-0003-0047-9616)
- Yi Zheng (ORCID: https://orcid.org/0000-0002-2351-3445)
- Xiaoqin Tang (ORCID: https://orcid.org/0000-0003-1753-8483)
- Yanyan Huang (ORCID: https://orcid.org/0009-0001-6071-3905)
Institutions
- Southwest General Health Center (US)
- Southwest Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fonc.2025.1557245
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Centre Scientifique et Technique du Bâtiment