Exploring the mechanism of Qingre Yishen Xiaozheng formula in treating diabetic kidney disease via the HIF-1α/HO-1 signaling pathway: an integrated network pharmacology and experimental study
QRYSXZF alleviates DKD progression by modulating the HIF-1α/HO-1 pathway to reduce ferroptosis, oxidative stress, and iron overload, providing a scientific basis for its clinical application in DKD management.
Authors
- Yaoxian Wang (ORCID: https://orcid.org/0000-0002-1927-9529)
- Jia‐Wen Shou (ORCID: https://orcid.org/0000-0002-2274-6802)
- Huijuan Zheng (ORCID: https://orcid.org/0000-0002-0389-3989)
- Z. Ryan Tian (ORCID: https://orcid.org/0000-0002-5644-8483)
- Fei Han (ORCID: https://orcid.org/0000-0002-7020-5963)
- Lanying Liu (ORCID: https://orcid.org/0000-0002-5242-2681)
- Weijing Liu
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fphar.2025.1661050
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07