CORRELATION BETWEEN SERUM AMYLASE AND CHOLINESTERASE IN OP POISONING

Introduction: Organophosphorus compounds constitute a varied category of chemicals employed as pesticides. Poisoning due to OP compounds is often reported, usually either intentional or accidental ingestion. In the past, cholinesterase levels served as the main indicator for assessing the severity of OP poisoning; however, serum amylase is currently being taken into account as well. Aim: To investigate the levels of plasma cholinesterase and serum amylase in instances of acute organophosphorus poisoning, and to establish a correlation between serum amylase levels and plasma cholinesterase levels. Materials and methods: A total of 120 patients with OP poisoning admitted in Sri Venkateswara medical college& hospital were included in the study within 24 hours following the incident. Blood samples were collected from each patient upon admission, on the 3rd day, and on the 5th day, and sent to the laboratory for the assessment of cholinesterase and serum amylase levels. Results: The majority of patients (42.5%) were in the age range of 21-30 years, with a higher incidence among males (57.5%). There were 47 (39.1%) farmers, 39 (32.5%) students, and 34 (28.3%) housewives. Upon admission, the average plasma concentration of cholinesterase was 3661 U/L, while serum amylase averaged 191.2 U/L. Compared to baseline values, a significant increase in mean plasma cholinesterase and a decrease in mean serum amylase were observed on both the 3rd and 5th days of treatment. This trend of increasing plasma cholinesterase and decreasing serum amylase was statistically significant (p<0.05). A significant negative correlation was observed between plasma cholinesterase and serum amylase levels. Conclusion: The current research concludes that the average plasma cholinesterase levels decline while serum amylase levels rise in cases of OP poisoning. As treatment progresses and the severity diminish, there is a reversal of the trend, leading to an increase in plasma cholinesterase levels and a decrease in serum amylase levels.