Comparison of oliceridine and sufentanil in patient - controlled intravenous analgesia for post - thoracoscopic nausea and vomiting: a prospective, double - blind, randomized controlled trial
In high-PONV-risk thoracoscopic surgery, oliceridine-based PCIA significantly reduced PONV incidence compared to sufentanil (32.3% vs. 50.8%, P = 0.033), while also demonstrating superior recovery quality (QoR-15) and sleep outcomes (AIS). This establishes oliceridine as a procedure-specific analgesic option for enhancing recovery beyond conventional opioid-sparing effects.
Authors
- Sanyi Yuan (ORCID: https://orcid.org/0000-0001-5253-6585)
- Su Liu
- Hengrui Zhang (ORCID: https://orcid.org/0000-0002-3183-1654)
- Zhiyu Ling (ORCID: https://orcid.org/0000-0003-1138-9528)
- Yifan Meng (ORCID: https://orcid.org/0000-0003-2988-8763)
- Chenyang Shi (ORCID: https://orcid.org/0000-0002-2291-7325)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3617-2627)
- Yujun Liu (ORCID: https://orcid.org/0000-0002-0375-5041)
- Kang Zhou (ORCID: https://orcid.org/0000-0002-7237-2247)
- Yang Niu
- Linlin Zhao
- Zhibiao Xu
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fphar.2025.1576154
- Citations
- 3
- Primary Topic
- Nausea and vomiting management
- Type
- article
- Field-Weighted Citation Impact
- 6.02