GSTP1 improves CAR-T cell proliferation and cytotoxicity to combat lymphoma
BLIMP1 directly suppressed GSTP1 transcription, whereas GSTP1 overexpression enhanced the antitumor capacity of CAR-T cells and maintained redox homeostasis, providing a novel therapeutic strategy to improve CAR-T cell immunotherapy.
Authors
- Yuliang Qu
- Jiani Wang (ORCID: https://orcid.org/0000-0002-0618-8337)
- Guangxian Xu
- Ning Jing (ORCID: https://orcid.org/0000-0002-4144-4658)
- Ying Li (ORCID: https://orcid.org/0000-0001-6664-0084)
- Xuebo Han (ORCID: https://orcid.org/0000-0002-3638-4312)
- Yan-ting Yann Zhang (ORCID: https://orcid.org/0000-0001-8647-9021)
- Hongxia Wang (ORCID: https://orcid.org/0000-0003-4876-2138)
- Le Guo (ORCID: https://orcid.org/0000-0001-9774-1400)
- Guangsong Xu
- Yun-Xia Shi
Institutions
- Guangdong Medical College (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1665407
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Ningxia Medical University