GNA13 promotes brain metastasis of non-small cell lung cancer and EMT through the WNT/β catenin signaling pathway
This study identifies <i>GNA13</i> as a key gene of lung cancer BM. <i>GNA13</i> promotes EMT and enhances the proliferation and metastatic capacity of lung cancer cells by activating the Wnt/β-catenin signaling pathway. These findings suggest that <i>GNA13</i> may serve as a potential therapeutic target for preventing or treating BM in NSCLC.
Authors
- Jing Cai (ORCID: https://orcid.org/0000-0002-6792-4959)
- Jiaqi Wu (ORCID: https://orcid.org/0000-0001-7737-5597)
- Ruo-Yue Fan
- Ming-Fang He
- Jin Xiang
- Ping Wei
Institutions
- Nanjing Tech University (CN)
- Jiangsu Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fcell.2025.1652200
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00