Palladium‐Catalyzed Four‐Component Radical Carbonylation Reaction for the Construction of Benzofuranamide Derivativesitle
A novel palladium‐catalyzed four‐component radical tandem cyclization‐carbonylation of 1,6‐enynes with aniline, carbon monoxide, and ethyl difluoroiodoacetate is reported. This approach facilitates a multicomponent reaction involving tandem 1,2‐double bond migration, thereby allowing the efficient synthesis of alkylamide‐substituted benzofuranamide derivatives. The proposed strategy demonstrates a broad substrate scope, high efficiency in bond migratory‐rearrangement, and controllable selectivity in the order of component addition.
Authors
- Dong‐Yu Miao
- Xi‐Cun Wang (ORCID: https://orcid.org/0000-0003-3770-9817)
- Shun‐Xi Li
- Yi‐Feng Qiu (ORCID: https://orcid.org/0000-0002-2747-9598)
- Chen Dong-pin
- Xin Gao (ORCID: https://orcid.org/0000-0001-7160-2066)
- Xiaojun Liu (ORCID: https://orcid.org/0000-0001-5694-202X)
- Zheng‐Jun Quan (ORCID: https://orcid.org/0000-0002-4393-3594)
- Ming Li (ORCID: https://orcid.org/0000-0002-1060-097X)
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1002/ejoc.202500539
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00