One Health Probiotics in Green Microbial Technologies

The “One Health” concept, traditionally centered on zoonotic pathogens and infectious disease management, has evolved to embrace the broader ecological interplay between humans, animals, and the environment. In recent decades, the accelerating challenge of antibiotic resistance has highlighted the fluid boundaries between pathogenic and commensal microorganisms, emphasizing that nature tolerates no strict divisions. Antibiotic resistance genes can readily transfer across microbial populations, blurring the lines between healthpromoting and pathogenic species. Consequently, modern “One Health” strategies must not only manage existing pathogenic threats but also foster sustainable microbial ecosystems that prevent future pathogen emergence. In this context, commensal and probiotic microorganisms play a vital role in stabilizing environmental, animal, and human microbiomes, serving as key agents in Green Microbial Technologies. This paper explores the paradigm shift from pathogen‐centered control to microbiome‐centered prevention, proposing that reinforcing beneficial microbial networks offers a sustainable, preventive approach to maintaining One Health at the agroecological interface.