Research Progress on the Roles of Formononetin in Protecting Organ Injury and Promoting Regeneration and Repair

Formononetin (FMN) is a kind of flavonoid compound extracted from Astragalus membranaceus, Radix Puerariae and other plants. Extensive research has demonstrated that FMN possesses various biological activities, including anti-tumor, antioxidant, anti-inflammatory, immunomodulatory, estrogen-like and other biological activities, indicating a broad application prospect in many fields, such as tumor, osteoporosis, diabetes, cardiovascular and cerebrovascular diseases, and perimenopausal syndrome. Recent studies have extensively investigated the roles of FMN in different organ injuries and the regeneration and repair of these organs. And found that it has protective and regenerative repair effects on multiple organ injuries, including the hematopoietic immune system, cardiovascular system, nervous system, digestive system, respiratory system, urogenital system, and skeletal system. This study reviewed the impact and mechanism of FMN in the repair of multi-organ injuries, providing a theoretical basis for further elucidating the medicinal value of FMN and guiding its rational development and application.