Global Psoriasis Burden 1990–2021: Evolving Patterns and Socio-Demographic Correlates in the Global Burden of Disease 2021 Update

<b>Background:</b> Psoriasis is a chronic immune-mediated disease affecting approximately 43 million individuals worldwide. While previous studies provide certain insights, there remains different conclusions and a lack of a comprehensive analysis regarding the burden of psoriasis. In response to ongoing therapeutic advances and a growing patient population, this study utilizes the Global Burden of Disease (GBD) 2021 estimates to characterize the spatiotemporal evolution of the psoriasis burden from 1990 through 2021. By integrating these biological, geographic, and socioeconomic determinants, this study aims to inform more targeted and effective health policy planning. <b>Methods:</b> To track changes over time, the Estimated Annual Percentage Change (EAPC) was determined using a linear regression model. In addition, a frontier analysis was utilized to investigate the link between psoriasis burden and socio-demographic progress. Furthermore, geographically weighted regression was used for the spatial econometric assessment of EAPC, age-standardized rates (ASRs), and Human Development Index (HDI) covariance structures across nation-states. <b>Results:</b> Between 1990 and 2021, the global burden of psoriasis increased consistently, with ASRs exhibiting a positive correlation with the Socio-demographic Index (SDI). High-SDI regions reported the highest burden, while high-middle-SDI regions experienced the steepest rise. <b>Conclusions:</b> This study reveals an increasing global psoriasis burden (1990-2021) through systematic analyses, indicating distinct regional progression patterns. These findings advocate for geographically tailored strategies to alleviate healthcare system pressures.