I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression

The results presented here suggest that BET inhibition therapy should be used with caution due to possible bimodal effects at high concentrations at the detriment of pancreatic beta cell function.

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Publication Details

Journal
Diabetologia
Published
2025-09-26
DOI
https://doi.org/10.1007/s00125-025-06541-0
Primary Topic
Protein Degradation and Inhibitors
Type
article
Field-Weighted Citation Impact
0.00

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article

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression

Yusuf Ali, Guy A. Rutter, Harish Babu, Bernett Teck Kwong Lee et al.
Diabetologia
Protein Degradation and Inhibitors
article

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression

Yusuf Ali, Guy A. Rutter, Harish Babu, Bernett Teck Kwong Lee, Daniel K. Y. Tan, Qing Wei Calvin Ho, Dewei Kong, Rosi Chelliah, Surabhi Devaraj, Adrian Kee Keong Teo, Xiaoling Wang, Divya Gunaseelan, James A. Miller, Vanessa Shiyun Tay, Xin Yan Chew
article en

Abstract

The results presented here suggest that BET inhibition therapy should be used with caution due to possible bimodal effects at high concentrations at the detriment of pancreatic beta cell function.

DiabetologiaVol. 68(12)
Agency for Science, Technology and Research (SG), National University of Singapore (SG), Nanyang Technological University (SG), McGill University Health Centre (CA), Khoo Teck Puat Hospital (SG), Precision for Medicine (United States) (US), Imperial College London (GB), All India Institute of Medical Sciences (IN), Université de Montréal (CA), Institute of Molecular and Cell Biology (SG)
Wellcome Trust, Diabetes UK, National Research Foundation, Nanyang Technological University, Lunds Universitet, Ministry of Education, India, National Institutes of Health, Canadian Institutes of Health Research, Medical Research Council, Institute of Molecular and Cell Biology, Lee Kong Chian School of Medicine, Nanyang Technological University, National Institute of Diabetes and Digestive and Kidney Diseases
Openalex Percentile: Top 77%
Protein Degradation and Inhibitors
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