I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression
The results presented here suggest that BET inhibition therapy should be used with caution due to possible bimodal effects at high concentrations at the detriment of pancreatic beta cell function.
Authors
- Yusuf Ali (ORCID: https://orcid.org/0000-0002-0681-1125)
- Guy A. Rutter (ORCID: https://orcid.org/0000-0001-6360-0343)
- Harish Babu (ORCID: https://orcid.org/0000-0001-8985-7526)
- Bernett Teck Kwong Lee (ORCID: https://orcid.org/0000-0002-2709-1972)
- Daniel K. Y. Tan (ORCID: https://orcid.org/0000-0003-0449-4557)
- Qing Wei Calvin Ho (ORCID: https://orcid.org/0000-0001-6281-7399)
- Dewei Kong
- Rosi Chelliah
- Surabhi Devaraj (ORCID: https://orcid.org/0000-0002-6224-9376)
- Adrian Kee Keong Teo (ORCID: https://orcid.org/0000-0001-5901-7075)
- Xiaoling Wang
- Divya Gunaseelan (ORCID: https://orcid.org/0009-0000-1515-7332)
- James A. Miller
- Vanessa Shiyun Tay
- Xin Yan Chew
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- McGill University Health Centre (CA)
- Khoo Teck Puat Hospital (SG)
- Precision for Medicine (United States) (US)
- Imperial College London (GB)
- All India Institute of Medical Sciences (IN)
- Université de Montréal (CA)
- Institute of Molecular and Cell Biology (SG)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1007/s00125-025-06541-0
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Diabetes UK
- National Research Foundation
- Nanyang Technological University
- Lunds Universitet
- Ministry of Education, India
- National Institutes of Health
- Canadian Institutes of Health Research
- Medical Research Council
- Institute of Molecular and Cell Biology
- Lee Kong Chian School of Medicine, Nanyang Technological University
- National Institute of Diabetes and Digestive and Kidney Diseases