Fat distribution, inflammatory mechanisms, and cardiovascular disease risk: mediation analysis based on the Framingham risk score
Different fat distribution patterns exert varying influences on long-term cardiovascular risk, with total body fat percentage showing the strongest association with increased risk. Inflammatory responses may serve as key biological mediators linking fat distribution to cardiovascular disease (CVD), highlighting the importance of monitoring and managing inflammation to reduce CVD risk.
Authors
- Hao Rao
- Zhuangzhuang Chen (ORCID: https://orcid.org/0000-0002-0336-1181)
- Mingzhong Xiao (ORCID: https://orcid.org/0000-0002-9462-2577)
- Jun Li (ORCID: https://orcid.org/0000-0002-8664-4813)
- Jia Zhang (ORCID: https://orcid.org/0000-0002-6079-2818)
- Zhi‐Li Xiao (ORCID: https://orcid.org/0000-0003-3901-0532)
- Wei Sun (ORCID: https://orcid.org/0000-0001-7511-529X)
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12872-025-05135-3
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Centers for Disease Control and Prevention