hPDLSC-ApoEVs attenuate periodontitis and enhance bone regeneration via NF-κB/S100A9-Mediated M2 macrophage polarization
In conclusion, these findings provide new evidence for the clinical application of hPDLSCs-ApoEVs in periodontitis treatment via macrophage immune modulation-mediated alveolar bone restoration.
Authors
- Jinlong Weng
- Weijie Peng (ORCID: https://orcid.org/0000-0003-0019-010X)
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Guanxiong Zhu
- Zeyu Zhang (ORCID: https://orcid.org/0000-0002-9095-2667)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-0580-2515)
- Yang Yu (ORCID: https://orcid.org/0000-0002-5481-5382)
- Zidan Xu
- Lingmin Zhang (ORCID: https://orcid.org/0000-0003-2284-1452)
- Lu Liang (ORCID: https://orcid.org/0000-0001-5373-8445)
- Dong Qin (ORCID: https://orcid.org/0000-0001-6200-5956)
- Liting Zeng
- Lina Yu (ORCID: https://orcid.org/0009-0003-2719-5004)
- Junyi Xia (ORCID: https://orcid.org/0009-0004-2431-9160)
Institutions
- Guangzhou Sport University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04617-7
- Citations
- 2
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Guangzhou Medical University
- Department of Education of Guangdong Province
- National Key Research and Development Program of China