Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing
The optimized surgical protocol presented here provides a simplified, reliable fetal mouse model with improved pregnancy success, reduced fetal loss, earlier implementation, and consistent phenotypic outcomes. This refined model enhances experimental efficiency, reproducibility, and animal welfare, having a major impact on mechanistic studies and therapeutic exploration for scarless skin regeneration.
Authors
- Chiakang Ho (ORCID: https://orcid.org/0000-0002-6861-7870)
- Qingfeng Li (ORCID: https://orcid.org/0000-0002-6954-2583)
- Lu Huang (ORCID: https://orcid.org/0000-0003-2834-3518)
- Yifan Zhang (ORCID: https://orcid.org/0009-0001-3030-9960)
- Xinran Ye
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Shanghai Jiao Tong University (CN)
- Massachusetts General Hospital (US)
- Shanghai Ninth People's Hospital (CN)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12575-025-00290-5
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Commission of Shanghai Municipality