A traditional herbal decoction regulates skeletal muscle satellite cell osteogenesis and myogenesis for repairing osteosarcopenic fractures via β-catenin
These findings provide the first evidence that the HD, as a β-catenin agonist, not only promotes fracture healing by modulating the osteogenic and myogenic effects of SMSCs but also ameliorates sarcopenia. This study offers practical evidence supporting the formula as a promising therapeutic candidate for treating osteosarcopenic fractures.
Authors
- Zhenxiong Jin
- Weiwei Da (ORCID: https://orcid.org/0000-0002-9752-3355)
- Xiang Gao (ORCID: https://orcid.org/0000-0003-1993-763X)
- Yi Shen (ORCID: https://orcid.org/0000-0001-8403-9882)
- Yongjian Zhao (ORCID: https://orcid.org/0000-0002-9053-6049)
- Wan Hong-bo
- Dezhi Tang (ORCID: https://orcid.org/0000-0002-6528-0731)
- Yan Li (ORCID: https://orcid.org/0000-0003-0316-7810)
- Qi Shi (ORCID: https://orcid.org/0000-0001-8743-1134)
- Xuequn Wu
- Hao Xu (ORCID: https://orcid.org/0000-0002-8311-506X)
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Huadong Hospital (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04642-6
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00