Impact of Epigenome-Wide Methylation and Breast Cancer Recurrence in Women Tested Negative for BRCA Genes: The Breast Methylation Risk (BREMERI) Study
Our exploratory study suggests that specific DNA methylation patterns in WBCs, particularly in genes related to cellular proliferation, invasion, and glucose homeostasis, may be associated with the risk of breast cancer recurrence in <i>BRCA</i> wild-type women. If validated in larger cohorts, these circulating signatures may serve as blood-based biomarkers to improve risk stratification and guide tailored treatment strategies.
Authors
- Debora Macis (ORCID: https://orcid.org/0000-0002-0633-2933)
- Monica Marabelli (ORCID: https://orcid.org/0000-0003-4216-230X)
- Mariarosaria Calvello (ORCID: https://orcid.org/0000-0003-2113-8503)
- Sara Gandini (ORCID: https://orcid.org/0000-0002-1348-4548)
- Davide Serrano (ORCID: https://orcid.org/0000-0002-2945-4108)
- Francesca Fava (ORCID: https://orcid.org/0000-0002-4363-2353)
- Sara Cagnacci (ORCID: https://orcid.org/0000-0003-1721-8332)
- Federica Bellerba (ORCID: https://orcid.org/0000-0002-5956-4340)
- Silvia Polidoro (ORCID: https://orcid.org/0000-0003-2968-0575)
- Irène Feroce (ORCID: https://orcid.org/0000-0001-9312-2020)
- Valentina Aristarco (ORCID: https://orcid.org/0000-0002-4939-6240)
- Harriet Johansson (ORCID: https://orcid.org/0000-0002-4131-2030)
- Cristina Zanzottera
- Aliana Guerrieri‐Gonzaga (ORCID: https://orcid.org/0000-0003-1915-1688)
- Giovanni Cugliari (ORCID: https://orcid.org/0000-0002-6080-0718)
- Bernardo Bonanni (ORCID: https://orcid.org/0000-0003-3589-2128)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Turin (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3390/cancers17193132
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministero della Salute