Disentangling the Effects of Suicide Attempts and Psychiatric Diagnosis Based on a Genotype-Informed Dynamic Model of the Serotonin Presynapse
Model-derived 5-HT profiles were shaped primarily by diagnosis, while temporal dynamics of 5-HIAA, rather than its absolute levels, was associated with suicide attempt status. Thus, personalized dynamic modeling incorporating genetic variants may aid in detecting subtle molecular signatures across diagnoses and suicidal behavior.
Authors
- Dušanka Savić‐Pavićević (ORCID: https://orcid.org/0000-0002-2079-4077)
- Jovan Pešović (ORCID: https://orcid.org/0000-0002-8304-2067)
- Lana Radenković (ORCID: https://orcid.org/0000-0002-8213-2781)
- Maja Pantović-Stefanović (ORCID: https://orcid.org/0000-0002-2263-0885)
- Maja Ivković (ORCID: https://orcid.org/0000-0003-1976-2075)
- Goran Brajušković (ORCID: https://orcid.org/0000-0002-3935-6755)
Institutions
- University of Belgrade (RS)
- Univerzitetski Klinički Centar Srbije (RS)
Publication Details
- Journal
- Genes
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3390/genes16101141
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00