Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations
Our data indicate that polymorphisms at positions 77 and 80 in the Meq of low-virulence strains reduce MDV virulence and Meq-mediated transcription and possibly alter pathogenesis. This study improves our understanding of the mechanisms underlying MDV virulence.
Authors
- Shwe Yee Win
- Hiroshi Saeki (ORCID: https://orcid.org/0000-0001-7243-6960)
- Satoru Konnai (ORCID: https://orcid.org/0000-0002-3230-7109)
- Tomohiro Okagawa (ORCID: https://orcid.org/0000-0002-1391-9732)
- Naoya Maekawa
- Nikolaus Osterrieder (ORCID: https://orcid.org/0000-0002-5313-2176)
- Aoi Kurokawa
- Satoru Yamagami (ORCID: https://orcid.org/0000-0002-1330-5386)
- Jumpei Sato (ORCID: https://orcid.org/0000-0001-6032-1584)
- Kazuhiko Ohashi (ORCID: https://orcid.org/0000-0002-7513-640X)
- Mark S. Parcells (ORCID: https://orcid.org/0000-0003-0311-3820)
- Yoshinosuke Motai
- Shiro Murata
- Fumiya Horio
Institutions
- Hokkaido University of Science (JP)
- National Agriculture and Food Research Organization (JP)
- University of Veterinary Medicine Hannover, Foundation (DE)
- Hokkaido University (JP)
- Sapporo International University (JP)
- Department of Disease Control (TH)
- National Institute of Animal Health (JP)
- Freie Universität Berlin (DE)
- University of Delaware (US)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12985-025-02930-4
- Citations
- 1
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Japan Society for the Promotion of Science