Genetic variants (LhcgrW495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression
This study verifies that Genetic variants (Lhcgr<sup>W495X/+</sup>) and environmental toxicants (DEHP) synergistically induce DSD, thereby elucidating the pathogenesis of DSD. Interfering with steroidogenic gene expression may be an important synergistical mechanism. This finding highlights the clinical imperative to minimize prenatal exposure to endocrine disruptors, particularly in pregnancies with variants of DSD.
Authors
- Kai Xia (ORCID: https://orcid.org/0000-0002-8369-3433)
- Gao Yong
- Xie Qigen (ORCID: https://orcid.org/0000-0003-0991-9219)
- Cao Haiming
- Chunhua Deng (ORCID: https://orcid.org/0000-0002-4969-2875)
- Zhe Xu (ORCID: https://orcid.org/0000-0003-2226-1191)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13293-025-00753-0
- Citations
- 1
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China