Macrophage Histone Deacetylase 4 Has Sex‐Dependent Dimorphic Effects on the Pathogenesis of Alcohol‐Associated Hepatitis
This study indicates that macrophage HDAC4 plays a sex-dependent role in the pathogenesis of alcohol-associated hepatitis, with its deletion attenuating alcohol-induced hepatic oxidative stress and inflammation in female mice while oxidative stress was aggravated in males.
Authors
- Mi‐Bo Kim (ORCID: https://orcid.org/0000-0002-0217-0244)
- Hyungryun Jang
- Young‐Ki Park
- Adam Kim (ORCID: https://orcid.org/0000-0002-3186-3912)
- Olivia Corvino
- Ji‐Young Lee (ORCID: https://orcid.org/0000-0002-7945-793X)
- Yoojin Lee (ORCID: https://orcid.org/0000-0003-2475-5857)
- Jae‐Eun Lee (ORCID: https://orcid.org/0000-0002-2985-9711)
- Hyunju Kang
Institutions
- University of Connecticut (US)
- Keimyung University (KR)
- UConn Health (US)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1111/jgh.70091
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00