SARS-CoV-2 при беременности: риски осложнений, плацентарная патология и эффективность вакцин о профилактики

The COVID-19 pandemic has significantly impacted global public health, with pregnant women identified as a high-risk group. This systematic review and meta analysis of 127 studies (n=489 532) examine the effects of SARS-CoV-2 infection on pregnancy, maternal and neonatal outcomes, placental pathology, and the efficacy of vaccination. Key findings include a 2,5-fold increase in maternal mortality in low income countries, a 68% incidence of placental histological abnormalities, and a 62% higher risk of preeclampsia among infected pregnant women. Vaccination, particularly with mRNA vaccines (Pfizer-BioNTech and Moderna), demonstrated high efficacy (91–93%) in preventing severe outcomes and was safe, with no increased risk of congenital anomalies or preterm birth. These results underscore the importance of vaccination, close monitoring, and thromboprophylaxis for pregnant women during the pandemic.