PINK1 functions in mitophagy and mitochondrial homeostasis during mice oocyte maturation
Collectively, our data display critical functions for PINK1 in meiotic progression and mitochondrial homeostasis in murine oocytes, and RAB8A activity is required for PINK1-mediated mitophagy in senescent oocytes.
Authors
- Shenming Zeng (ORCID: https://orcid.org/0000-0003-2188-6122)
- Yixiao Zhu
- Shiwei Wang (ORCID: https://orcid.org/0000-0002-6836-8229)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0003-3207-498X)
- Shuang Song (ORCID: https://orcid.org/0000-0002-3490-9752)
- Yajun Guo (ORCID: https://orcid.org/0000-0002-9649-0045)
- Xuan Wu
Institutions
- Peking University (CN)
- Ministry of Agriculture (ID)
- Peking University Third Hospital (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13578-025-01460-4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation