Low Yield of Genetic Testing in Serrated Polyposis Syndrome
Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing seems to have limited utility in patients with SPS and may primarily identify those with an incidental diagnosis of Lynch syndrome.
Authors
- Andrew R. Latchford (ORCID: https://orcid.org/0000-0002-8626-188X)
- Kevin John Monahan (ORCID: https://orcid.org/0000-0002-7918-4003)
- Victoria Cuthill
- Husam Al Maliki (ORCID: https://orcid.org/0009-0005-3803-1376)
- Ira Upadhye
Institutions
- Norfolk and Norwich University Hospitals NHS Foundation Trust (GB)
- St Mark's Hospital (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.14309/ctg.0000000000000923
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47