“ANALYTICAL METHODS FOR THE ESTIMATION OF SAFINAMIDE AND LEVODOPA: A COMPREHENSIVE REVIEW”

Parkinson's disease is a chronic neurological disorder that primarily impacts movement. It occurs when specific brain cells that produce a chemical known as dopamine begin to die. This results in common symptoms such as difficulties with balance, stiff muscles, lack of movement, and shaking. Parkinson's disease patients may also experience non-motor symptoms such as anxiety or depression, issues with memory, or trouble falling asleep. While there is no cure, various treatments have been developed to help manage the symptoms of Parkinson's disease. Management of PD is a growing field and targets new treatment methods, as well as improvements to old ones. Pharmacological, surgical, and therapeutic treatments have allowed physicians to treat not only the main motor symptoms of Parkinson's disease. Medications like levodopa and safinamide are widely used to manage its symptoms. Levodopa is the most effective treatment for improving motor function, as it helps replenish dopamine levels. Safinamide is an add-on therapy used in combination with levodopa, which works by inhibiting monoamine oxidase-B (MAO-B) and modulating glutamate release. This combination helps reduce motor fluctuations and “off” periods, improving patients’ overall mobility and quality of life. Together, these treatments play a vital role in improving symptom control in individuals living with Parkinson’s disease, though ongoing research continues to seek a true cure.   KEYWORDS: