Longitudinal MRI identifies associations between cognitive decline, inflammatory markers, and hippocampal subregion volumes in individuals with knee osteoarthritis
Fimbria serves as a key pathway through which KOA may drive cognitive impairment, while IFN-γ could help protect memory. Monitoring these hippocampal changes and inflammation levels might help identify at-risk patients early.
Authors
- Guiyan Cai
- Jiao Liu (ORCID: https://orcid.org/0000-0002-2708-8298)
- Jing Tao (ORCID: https://orcid.org/0000-0002-4895-2065)
- Peiling Zeng
- Ming Li (ORCID: https://orcid.org/0000-0002-1953-4526)
- Yajun Wang (ORCID: https://orcid.org/0000-0002-7557-5883)
- Baoru Zhao
- Ruilin Chen (ORCID: https://orcid.org/0000-0002-8223-5481)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Capital Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Fuzhou Second Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1038/s43856-025-01104-1
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Fujian University of Traditional Chinese Medicine