Gestational age and models for predicting gestational diabetes mellitus

The late pregnancy urine metabolites independently linked to GDM were markers for diminished insulin sensitivity and glucose-stimulated insulin release. The high predictive accuracy of the models in both early and late pregnancy in this cohort supports the notion that a urinary metabolite phenotype may separate GDM vs CON across both early and late gestation. A large validation study should be conducted to affirm the accuracy of this noninvasive and time-efficient technology in identifying GDM.