Advancing Pyrogen Testing for Vaccines with Inherent Pyrogenicity: Development of a Novel Reporter Cell-Based Monocyte Activation Test (MAT)
The implementation of reporter cell-based MAT assays enhances consistency, reliability, and efficiency in evaluating the pyrogenicity and safety of drug products, supporting global initiatives to minimize animal testing while ensuring regulatory compliance.
Authors
- Christopher J. Wang
- Shuhua Yi (ORCID: https://orcid.org/0000-0002-6291-812X)
- Melissa C. Whiteman (ORCID: https://orcid.org/0000-0002-8967-599X)
- Frank Celeste (ORCID: https://orcid.org/0000-0002-4796-2026)
- Liping Song (ORCID: https://orcid.org/0000-0001-6558-3137)
- Jenny Xu
Institutions
- United States Military Academy (US)
- Decision Sciences (United States) (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3390/vaccines13101009
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35