Recombinant Methioninase Selectively Eliminates Cancer Cells Co-cultured With Normal Fibroblasts Indicating the High-Precision Efficacy of Targeting Methionine Addiction of Cancer
The differential sensitivity of cancer and normal cells to rMETase at 0.46 U/ml was so extensive that cancer cells were essentially eliminated from the co-cultures while the normal cells remained viable and proliferating. The difference in sensitivity of normal and cancer cells growing together suggests that rMETase selectively and precisely targets methionine addiction of cancer and can be a safe and effective clinical anti-cancer agent.
Authors
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- SHUKUAN LI
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- KOHEI MIZUTA
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0002-1847-3741)
- Robert M. Hoffman
- Qinghong Han
- YUTA MIYASHI
Institutions
- Hallym University (KR)
- University of California San Diego (US)
- AntiCancer (United States) (US)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17771
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23