Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitis
An inherited deficiency of IL-18BP, a soluble antagonist of IL-18, was previously reported in an otherwise healthy Algerian patient who died of fulminant viral hepatitis A at the age of 11 years. We describe here an Egyptian family with two siblings who died at the ages of two years and seven months of fulminant viral hepatitis (FVH) following infection with hepatitis A virus.
Authors
- Serkan Belkaya (ORCID: https://orcid.org/0000-0003-4214-382X)
- Adrian Gervais (ORCID: https://orcid.org/0000-0002-1083-5787)
- Xiao‐Fei Kong (ORCID: https://orcid.org/0000-0001-9983-2373)
- Jean‐Laurent Casanova (ORCID: https://orcid.org/0000-0002-7782-4169)
- Emmanuelle Jouanguy (ORCID: https://orcid.org/0000-0002-7358-9157)
- Vivien Béziat (ORCID: https://orcid.org/0000-0002-4020-824X)
- Dalia Abd Elaziz (ORCID: https://orcid.org/0000-0002-7830-7008)
- Aysima Atılgan Lülecioğlu
- Chenglin Zhang (ORCID: https://orcid.org/0009-0002-1156-6715)
- Alperen Baran
- Hanaa El‐Karaksy (ORCID: https://orcid.org/0000-0002-8479-2847)
Institutions
- Howard Hughes Medical Institute (US)
- Cairo University (EG)
- Inserm (FR)
- Bilkent University (TR)
- Université Paris Cité (FR)
- Hospital for Sick Children (CA)
- Hospital for Sick Children Pediatric Center (US)
- Alder Hey Children's NHS Foundation Trust (GB)
- Southwestern Medical Center (US)
- Human Genetic of Infectious Diseases (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Rockefeller University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2025-09-26
- DOI
- https://doi.org/10.70962/jhi.20250135
- Citations
- 4
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- St. Giles Foundation
- Institut des maladies génétiques Imagine
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Center for Advancing Translational Sciences