Assessing the oncologic risk when systematic and multiparametric magnetic resonance imaging–targeted prostate biopsy grade groups are discordant
When the grade group is discordant between systematic biopsy and targeted biopsy, the risk is intermediate. The current approach of assigning the highest grade group should be abandoned, and urologists should consider deescalating treatment intensity for patients with discordant systematic biopsy and MRI-targeted biopsy grade groups. Our findings are plausibly explained by pattern 4 volume being the primary driver of risk.
Authors
- Johnny Wang (ORCID: https://orcid.org/0000-0001-5021-681X)
- Julien Sarkis (ORCID: https://orcid.org/0000-0002-5060-0819)
- Otto Ettala (ORCID: https://orcid.org/0000-0003-1011-4602)
- Christopher Gaffney (ORCID: https://orcid.org/0000-0002-7785-6611)
- Behfar Ehdaie (ORCID: https://orcid.org/0000-0003-2949-0632)
- Francesco Barletta (ORCID: https://orcid.org/0000-0003-3585-3217)
- Tobias Nordström (ORCID: https://orcid.org/0000-0003-4915-7546)
- Michael Muentener
- Andrew Julian Vickers (ORCID: https://orcid.org/0000-0003-1525-6503)
- Charles Dariane (ORCID: https://orcid.org/0000-0002-9573-2938)
- Johnny Wang
- J. Anract (ORCID: https://orcid.org/0009-0006-7580-1066)
- Alec Zhu (ORCID: https://orcid.org/0000-0003-1935-483X)
- Olivier Windisch (ORCID: https://orcid.org/0000-0002-8963-5445)
- Vincent P. Laudone (ORCID: https://orcid.org/0000-0001-9263-9415)
- Anthony Kanbar (ORCID: https://orcid.org/0000-0002-7767-7066)
- Martin Umbehr
- Amy L. Tin (ORCID: https://orcid.org/0000-0002-8005-0694)
- Francesco Montorsi (ORCID: https://orcid.org/0000-0002-7267-4181)
- Martin Andreas Røder (ORCID: https://orcid.org/0000-0002-0019-5333)
- Benedicte Guillaume
- Armando Stabile (ORCID: https://orcid.org/0000-0002-3700-0069)
- Gopal Nand Gupta (ORCID: https://orcid.org/0000-0002-8502-708X)
- Thibault Tricard (ORCID: https://orcid.org/0000-0002-2472-3575)
- Jennifer Pan (ORCID: https://orcid.org/0000-0001-6713-6402)
- Romain Diamand (ORCID: https://orcid.org/0000-0002-2016-8543)
- Jonathan Olivier (ORCID: https://orcid.org/0000-0002-5409-2911)
- Simone Scuderi (ORCID: https://orcid.org/0000-0003-0071-1868)
- Timo Soeterik (ORCID: https://orcid.org/0000-0002-0259-8750)
- Bénédicte Guillaume
- Ahmad Abbadi (ORCID: https://orcid.org/0000-0001-9373-668X)
- G. Fiard (ORCID: https://orcid.org/0000-0003-3049-5318)
- Fabio Zattoni (ORCID: https://orcid.org/0000-0002-4178-373X)
- Lorenzo Bianchi (ORCID: https://orcid.org/0000-0001-7321-1536)
- Peter J. Boström (ORCID: https://orcid.org/0000-0003-3647-0015)
- Daniel Benamran (ORCID: https://orcid.org/0000-0003-1287-0567)
- Parsa Iranmahboub
- Eric H. Kim (ORCID: https://orcid.org/0000-0002-0284-8342)
- Yanqin Wang (ORCID: https://orcid.org/0000-0002-1161-0467)
- Kshitij Pandit (ORCID: https://orcid.org/0009-0003-0105-4430)
- Jim C. Hu (ORCID: https://orcid.org/0000-0003-3406-5542)
- Tobias Nordström
- Alexandre de la Taille
- James A. Eastham
- Lorenzo Bianchi
- Harm H E van Melick
- Umberto Cimmino
- Umberto Cimmino
Institutions
- Northwestern University (US)
- University of Geneva (CH)
- University of Copenhagen (DK)
- Loyola University Medical Center (US)
- Université Libre de Bruxelles (BE)
- Memorial Sloan Kettering Cancer Center (US)
- University of Nevada, Reno (US)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Turku (FI)
- Shanghai Jiao Tong University (CN)
- Université Paris-Est Créteil (FR)
- Washington University in St. Louis (US)
- Cornell University (US)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Renji Hospital (CN)
- Institut Jules Bordet (BE)
- Turku University Hospital (FI)
- Danderyds sjukhus (SE)
- Copenhagen University Hospital (DK)
- Karolinska Institutet (SE)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Hôpital de la Croix-Rousse (FR)
- Hôpital Beau-Séjour (CH)
- Presbyterian Hospital (US)
- Geopartner (Poland) (PL)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Glanrhyd Hospital (GB)
- Northwestern University (PH)
- University Hospital of Zurich (CH)
- St. Antonius Ziekenhuis (NL)
- Mylan (South Africa) (ZA)
- Nanjing Drum Tower Hospital (CN)
- Azienda USL di Bologna (IT)
- Essen University Hospital (DE)
- German Marine Research Consortium (DE)
- Prostate Cancer UK (GB)
- Northwestern Medicine (US)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1093/jnci/djaf275
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00