A multifaceted hybrid ES-robotic device for gait training in individuals with neurological disorders
The integration of robotics and Electrical Stimulation (ES) in neurorehabilitation leverages robotics' precise task execution alongside ES-induced motor learning, muscle conditioning, and cardiovascular benefits. We propose a hybrid system for overground gait training, combining neuromuscular ES and a motorized exoskeleton. Different combination modalities are proposed: ES-motor cooperation for the swinging knee, synchronized but independent ES and motor assistance for hip movements and for the knee during stance, and ES-only for the non-actuated ankle. Twelve non-disabled subjects and eleven participants with neurological disorders tested the system under two conditions: exoskeleton-only and hybrid. The hybrid condition reduced knee motor torque by 48% during swing without compromising tracking accuracy, showing that ES can effectively drive limb motion. Neurological participants rated the hybrid system as more usable than the exoskeleton alone (median 5-point improvement of System Usability Scale). These findings support the feasibility of hybrid ES-motorized exoskeletons in clinical settings. Future studies should investigate their potential to enhance therapeutic outcomes.
Authors
- Stefano Maludrottu
- Alessandra Pedrocchi (ORCID: https://orcid.org/0000-0001-9957-2786)
- Francesca Dell’Eva (ORCID: https://orcid.org/0009-0007-3777-0964)
- Giancarlo Ferrigno (ORCID: https://orcid.org/0000-0001-5913-9451)
- Marta Gandolla (ORCID: https://orcid.org/0000-0001-5237-714X)
- Emanuele Gruppioni (ORCID: https://orcid.org/0000-0003-0732-8378)
- Eleonora Guanziroli (ORCID: https://orcid.org/0000-0002-7512-5372)
- Emilia Ambrosini (ORCID: https://orcid.org/0000-0002-6527-0779)
- Franco Molteni
- Laura Brignole
- Viola Camerini
Institutions
- Italian Institute of Technology (IT)
- Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro (IT)
- Ospedale Valduce (IT)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1038/s41467-025-63474-3
- Citations
- 2
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro