Association of serum inflammasome proteins and pediatric traumatic brain injury severity
Increased serum levels of inflammasome proteins ASC and caspase-1 in acute-phase post-admission samples are associated with severe TBI. To our knowledge, this is the first study to examine the inflammasome pathway in pediatric TBI patients across the severity spectrum using serum samples. The study enhances our understanding of NLRP3 inflammasome activation in pediatric TBI by profiling serum levels and examining their clinical correlation with injury severity. It suggests an adjunctive approach to the Glasgow Coma Scale with biomarkers for more precise TBI diagnosis. This research lays the groundwork for future therapeutic strategies targeting inflammasomes in pediatric TBI.
Authors
- Kathryn Swaby
- W. Dalton Dietrich (ORCID: https://orcid.org/0000-0002-8732-4942)
- Kristine O’Phelan (ORCID: https://orcid.org/0000-0002-5074-1232)
- Maria Mateo Chavez (ORCID: https://orcid.org/0009-0008-1011-8949)
- Julia Bernal
- Charlene Pringle (ORCID: https://orcid.org/0000-0003-3345-7827)
- Dhanashree Rajderkar (ORCID: https://orcid.org/0000-0002-5962-2854)
- Robert W. Keane (ORCID: https://orcid.org/0000-0003-4068-9511)
- Ayham M. Alkhachroum (ORCID: https://orcid.org/0000-0003-0352-5913)
- J.P. Solano (ORCID: https://orcid.org/0000-0001-7153-5633)
- Juan Pablo de Rivero Vaccari (ORCID: https://orcid.org/0000-0002-5460-8834)
- Jennifer C. Muñoz Pareja (ORCID: https://orcid.org/0000-0001-5647-0579)
- Kourtney Guthrie
- Nilton Carlos Machado (ORCID: https://orcid.org/0000-0003-4769-1139)
- Firas Kobeissy (ORCID: https://orcid.org/0000-0002-5008-6944)
- Joslyn Gober (ORCID: https://orcid.org/0000-0003-3323-093X)
- Jennifer Coto (ORCID: https://orcid.org/0000-0001-9009-0895)
- Kevin Wang (ORCID: https://orcid.org/0000-0002-9343-6473)
- Heather J. McCrea (ORCID: https://orcid.org/0000-0002-8433-3907)
- Damien Mosquera (ORCID: https://orcid.org/0000-0002-0818-1462)
Institutions
- Lincoln Medical Center (US)
- University of Miami (US)
- University of Florida (US)
- Jackson Health System (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
- Morehouse School of Medicine (US)
- Florida College (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1038/s41390-025-04410-5
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities