A Systematic Review and Meta-analysis of Mood Stabilizer in Treatment of Patients With Non-suicidal Self Injury in China (Preprint)

<sec> <title>BACKGROUND</title> Non-Suicidal Self-Injury(NSSI) refer to deliberate and repeated acts of damaging one's own body tissue without suicidal intent.It has have become a serious public health problem in the world.This study is to set a systematic review and meta-analysis for exploring effectiveness of mood stabilizer in treatment of depressive patients with NSSI in China. </sec> <sec> <title>OBJECTIVE</title> The literatue about patients with NSSI treated with mood stabilizer </sec> <sec> <title>METHODS</title> Chinese and English literature related to the treatment by mood stabilizer for NSSI in China were searched, comments, letters, reviews and case reports were excluded. The index of depression, anxiety, compulsion, self-injury, effectiveness in patients with was synthesized and discussed. </sec> <sec> <title>RESULTS</title> A total eight studies were included,in which,there were four comparative studies by control group and four was comparative studies by before and after treatment. The lower score of anxiety, depression, compulsion, self-injury were found compared to before treatment. It is found that lower score of anxiety, depression, self-injury in group treated with mood stabilize compared to group without mood stabilize. The results also showed that higher effective rate and lower onset rate of NSSI were found in group treated with mood stabilize compared to group treated without mood stabilizer. </sec> <sec> <title>CONCLUSIONS</title> The severity of anxiety, depression, impulsivity, and self injury was significantly reduced before and after treatment with mood stabilizers. Compared with not using mood stabilizers, anxiety, depression, and self injury were also significantly reduced, and the effective rate was significantly improved. The incidence of self injury was significantly reduced by mood stabilizer. These results fully demonstrate the important role of mood stabilizers in the treatment of NSSI. </sec> <sec> <title>CLINICALTRIAL</title> PROSPERO register: CRD420251143008 </sec>