Immunohistochemical Evaluation of Tumor Characteristic Retention in Triple-negative Breast Cancer PDOX Models
TNBC PDOX models are promising tools for preclinical drug evaluation; however, variability in the retention of molecular targets, such as AR, CK5/6, and HER2, emphasizes the importance of verifying marker expression prior to functional analysis. Tumor heterogeneity and clonal selection during engraftment may contribute to these discrepancies.
Authors
- Sachiko Inubushi (ORCID: https://orcid.org/0000-0003-0541-4942)
- Tomonari Kunihisa (ORCID: https://orcid.org/0000-0003-2805-6746)
- Sachiko Mizumoto
- Mayuko Miki
- Mayuko Yamamoto
- Motoi Baba
- Hirokazu Tanino (ORCID: https://orcid.org/0000-0002-6704-3641)
- SHOTARO INOUE
Institutions
- Wakayama Medical University (JP)
- Naga Municipal Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17769
- Citations
- 1
- Primary Topic
- bioluminescence and chemiluminescence research
- Type
- article
- Field-Weighted Citation Impact
- 0.81