The Genetic Role of Matrix Metalloproteinase-12 in Determining Childhood Acute Lymphocytic Leukemia Risk
While <i>MMP-12</i> rs2276109 and rs652438 polymorphisms do not appear to affect susceptibility to childhood ALL, rs652438 variant genotypes may serve as prognostic biomarkers for disease severity and outcome. Further functional validation and multicenter studies are warranted to confirm these findings and assess their clinical utility in childhood ALL risk stratification.
Authors
- Huey‐En Tzeng
- YUN-CHI WANG
- Chia‐Wen Tsai (ORCID: https://orcid.org/0000-0002-6698-7747)
- Te‐Chun Hsia (ORCID: https://orcid.org/0000-0003-4297-9918)
- JEN-SHENG PEI (ORCID: https://orcid.org/0000-0003-1775-4397)
- HOU-YU SHIH
- Pei‐Chen Hsu
- WEN-SHIN CHANG (ORCID: https://orcid.org/0000-0003-1735-2857)
- M. Y. Su
- DA-TIAN BAU
- CHAO-CHUN CHEN
Institutions
- Ministry of Health and Welfare (KR)
- Asia University (TW)
- China Medical University (TW)
- Taichung Veterans General Hospital (TW)
- Tao Yuan General Hospital (TW)
- China Medical University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17774
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University Hospital
- China Medical University
- Tao Yuan General Hospital, Ministry of Health and Welfare