Apalutamide Induces Dose and Time-dependent Apoptosis in C6 Glioma Cells Through Modulation of Key Apoptotic Regulators
In conclusion, this study provides the first evidence that apalutamide exerts cytotoxic and pro-apoptotic effects on C6 glioma cells, suggesting a potential off-target utility of androgen receptor antagonists in glioma treatment strategies. Further <i>in vivo</i> and mechanistic studies are warranted to elucidate the underlying pathways and therapeutic relevance.
Authors
- Ertan Katırcı (ORCID: https://orcid.org/0000-0002-3781-9162)
- SUNA KARADENIZ-SAYGILI
Institutions
- Ahi Evran University (TR)
- Kütahya Dumlupınar Üniversitesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17778
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00