BrainProt v3.0: An Integrative and Simplified Omics-Based Knowledge-Base About the Human Brain and Its Associated Diseases

The advancements in neuroscience research and omics technologies generate extensive data for brain-related diseases and disorders that are scattered across various manuscript repositories and databases, potentially hindering global initiatives to advance neuroscience research. This study introduces BrainProt v3.0 (https://www.brainprot.org/), an omics-driven knowledge-base of human brain and associated diseases. BrainProt version 3.0 navigates the Human Brain Disease Atlas (HBDA) and integrates the Brain Disease Marker Curator (BDMC) and Brain Disease Drug Finder (BDDF). It features 20,202 disease-associated genes, 136,557 chemical target interactions, and 2,145 clinical trial details. Additionally, the Brain Disease Transcriptome Map (BDTM) and Brain Disease Proteome Map (BDPM) collate multiomics data from the most significant brain diseases, displaying an expression profile across 52 datasets and 1,868 samples. This platform also facilitates the exploration of biological cross-talk and correlations between transcriptomics and proteomics data to identify critical disease-associated markers. In conclusion, BrainProt is designed to advance the Human Brain Proteome Project (HBPP) by expanding the integration of diseases and datasets, thereby elucidating the complexities of brain diseases and enhancing the research on the interplay between brain tumors and neurodegenerative disorders.