Antitumor Potential of Epigallocatechin Gallate in Overcoming Molecular Therapy Resistance in Hepatocellular Carcinoma
EGCG effectively counters resistance to molecular therapies in HCC by modulating stress-response proteins, RTK signaling, and miRNA profiles. miR-575 appears to mediate its antitumor activity, suggesting potential therapeutic value for EGCG and miR-575-based strategies in treating resistant HCC.
Authors
- Tomoko Tadokoro (ORCID: https://orcid.org/0000-0001-9975-386X)
- Hideki Kobara (ORCID: https://orcid.org/0000-0002-8508-827X)
- Akihiro Kitaoka
- M. Nakahara (ORCID: https://orcid.org/0000-0002-3227-0801)
- Joji Tani (ORCID: https://orcid.org/0000-0001-8801-2505)
- Tsutomu Masaki (ORCID: https://orcid.org/0000-0002-8425-0685)
- Shima Mimura (ORCID: https://orcid.org/0000-0002-9574-0479)
- Fumiyuki Suetsugu
- HISAKAZU IWAMA
- Kazuhito Sasaki (ORCID: https://orcid.org/0000-0003-3569-6944)
- Koji Fujita (ORCID: https://orcid.org/0000-0001-9390-7565)
- Kyoko Oura (ORCID: https://orcid.org/0000-0002-9531-7240)
- ASAHIRO MORISHITA
- Erika Omayu
Institutions
- Kagawa University (JP)
- Kagawa University Hospital (JP)
- Kashiwa Municipal Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17773
- Primary Topic
- Tea Polyphenols and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00