Relationship Between Angiogenesis and Hypoxia-inducible Factor-1α and Erythropoietin in Superficial Esophageal Carcinoma
In esophageal carcinoma, HIF-1α and Epo were strongly expressed at the earliest stages of carcinogenesis. As the carcinoma progressed beyond the muscularis mucosae, the expression of these markers significantly declined, suggesting a resolution of hypoxia likely associated with active angiogenesis.
Authors
- Youichi Kumagai (ORCID: https://orcid.org/0000-0001-9895-8820)
- Tetsuhiko Tachikawa
- Eisuke Yamamoto
- Hideyuki Ishida
- Masashi Oka
- M. Higashi
Institutions
- Saitama Cancer Center (JP)
- Social Insurance Saitama Chuo Hospital (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17772
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00