Isothiocyanates Enhance the Anti-melanoma Effect of Entinostat Through Modulation of Apoptosis and HDACs’ Expression Patterns in an <i>In Vitro</i> Model of Human Malignant Melanoma
We show evidence of an optimized experimental protocol capable of potentiating the anti-melanoma efficacy of ENT while maintaining a non-cytotoxic profile in non-tumorigenic cells.
Authors
- Aglaia Pappa (ORCID: https://orcid.org/0000-0003-0913-4315)
- Ioannis Paraskevaidis (ORCID: https://orcid.org/0000-0002-7764-6411)
- Rodrigo Franco (ORCID: https://orcid.org/0000-0003-3241-8615)
- Sotiris Kyriakou (ORCID: https://orcid.org/0000-0002-6195-6570)
- Ioannis Anestopoulos (ORCID: https://orcid.org/0000-0003-2052-8470)
- Dimitrios T. Trafalis (ORCID: https://orcid.org/0000-0003-4066-9780)
- Mihalis I. Panayiotidis
- Sotiris Botaitis
Institutions
- University of Nebraska–Lincoln (US)
- Democritus University of Thrace (GR)
- National and Kapodistrian University of Athens (GR)
- Cyprus Institute of Neurology and Genetics (CY)
- University of Pennsylvania (US)
- Mississippi State University (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.21873/anticanres.17768
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- European Commission
- Public Health England
- Hellenic Foundation for Research and Innovation
- European Regional Development Fund