The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified‐Release Posaconazole Prophylaxis
Although bIFD rate was consistent with other reports, mortality after bIFD remained significant. Use of mould-active AFP likely explained the changing epidemiology of fungal isolates. Resistant breakthrough fungal organisms, especially L. prolificans, reflected local epidemiology. Ongoing surveillance of IFD including resistant organisms is warranted to optimize treatment and patient outcome.
Authors
- Monica A. Slavin (ORCID: https://orcid.org/0000-0002-8443-314X)
- Shio Yen Tio (ORCID: https://orcid.org/0000-0002-2774-2237)
- Chin Fen Neoh (ORCID: https://orcid.org/0000-0003-2462-2958)
- Leon James Worth (ORCID: https://orcid.org/0000-0003-4304-6845)
- David C. M. Kong (ORCID: https://orcid.org/0000-0002-5022-9060)
- Michelle K. Yong (ORCID: https://orcid.org/0000-0002-8692-4145)
- David Ritchie (ORCID: https://orcid.org/0000-0002-9844-8350)
- Lynette Chee
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- National Cancer Centre Japan (JP)
- Cancer Australia (AU)
- Peter Doherty Institute (AU)
- Monash University (AU)
- Monash Institute of Medical Research (AU)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1111/tid.70104
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- MSD Australia