Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany
Sepsis long-term outcomes appear to be influenced by a complex interaction between age and sex. While our study focuses on these factors, it is important to acknowledge that observed associations cannot be attributed to biological sex alone, as numerous additional factors - directly or indirectly related to sex- may also contribute. These findings underscore the importance of incorporating sex-specific considerations into sepsis care and post-acute support strategies to improve long-term outcomes.
Authors
- Ha‐Yeun Chung (ORCID: https://orcid.org/0000-0002-6529-9176)
- Carolin Fleischmann-Struzek (ORCID: https://orcid.org/0000-0002-1104-3191)
- Melissa Spoden (ORCID: https://orcid.org/0000-0002-6730-4469)
- Diana Dudziak (ORCID: https://orcid.org/0000-0001-9358-134X)
- Stefan Hagel (ORCID: https://orcid.org/0000-0003-2999-6131)
- Mathias Wilhelm Pletz (ORCID: https://orcid.org/0000-0001-8157-2753)
- Patrik Dröge (ORCID: https://orcid.org/0000-0003-0263-3154)
- Jenny Rosendahl (ORCID: https://orcid.org/0000-0001-7535-7571)
- Norman Rose (ORCID: https://orcid.org/0000-0002-2908-205X)
- Christina E. Zielinski (ORCID: https://orcid.org/0000-0002-8184-0858)
- Irit Nachtigall (ORCID: https://orcid.org/0000-0002-9976-9295)
- Islam Agrama
Institutions
- Vivantes Klinikum (DE)
- Jena University Hospital (DE)
- Wissenschaftliches Institut der AOK (DE)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Publication Details
- Journal
- Critical Care
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13054-025-05657-4
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06