Gamma radiation-induced Vitamin E nanoparticles: scavenging free radicals in aqueous environments

Abstract Present study investigates the efficacy of Vitamin E nanoparticles (Vitamin E-NPs) compare with bulk Vitamin E in scavenging gamma radiation-induced free radicals in water. Vitamin E-NPs were synthesized by ball milling technique and characterized by UV-Visible, FTIR, XRD, TEM and FESEM. The result indicate that value of average crystallite size equal to (4.6 nm) beside mean particles diameter is (39.62 nm) whilst grain size is (30 nm), AFM analysis refers to relatively uniform distribution of roughly spherical nanoparticles. The antioxidant efficacy of Vitamin E-NPs was assessed via the DPPH assay, quantifying their capacity to neutralize free radicals produced by gamma irradiation. Results demonstrated that Vitamin E significantly reduced free radicals by Vitamin E concentrations-dependent manner, indicating their potent antioxidant capacity, this is confirmed by the inhibition results of radio protective as its value was (44.3, 87.9%) and radio treatment was (47.9, 90.1%) for Vitamin E as bulk and NPs respectively. Moreover, dispensability exhibited enhanced water dispensability and stability compared to bulk Vitamin E, facilitating their interaction with Reactive Oxygen Species (ROS) in aqueous mediums. These findings suggest that Vitamin E-NPs hold promise as an effective intervention for mitigating gamma radiation-induced oxidative stress, with potential applications in radiation protection.