Monolithic multimodal neural probes for sustained stimulation and long-term neural recording

Long-term implantable neural probes with dual-mode optical stimulation and simultaneous electrical recording are crucial for modulating neural loop activity in vivo. Traditional probes using "add-on" strategies often suffer from mechanical rigidity, compromised electrical performance, and insufficient biocompatibility, limiting their clinical applicability. In this study, we present a method for the direct laser writing of electrode arrays onto the curved surface of optical fibers, integrating them within a biocompatible polymer coating to create monolithic neural probes. The monolithic probes demonstrate high mechanical bending endurance, stable impedance, and improved biocompatibility, resulting in a lower inflammatory response compared to conventional systems. Furthermore, our method facilitates the multilayer integration of multilayer electrodes onto optical fibers, enabling high-density electrical readout channels. This advancement represents substantial progress in neuroengineering, with promising implications for future neural monitoring and modulation applications.

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Publication Details

Journal
Science Advances
Published
2025-09-26
DOI
https://doi.org/10.1126/sciadv.adu1753
Primary Topic
Neuroscience and Neural Engineering
Type
article
Field-Weighted Citation Impact
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article

Monolithic multimodal neural probes for sustained stimulation and long-term neural recording

Shaomin Zhang, Jikui Luo, Boyu Li, Hao Jin et al.
Science Advances
Neuroscience and Neural Engineering
article

Monolithic multimodal neural probes for sustained stimulation and long-term neural recording

Shaomin Zhang, Jikui Luo, Boyu Li, Hao Jin, Luxi Zhang, Gang Pan, Tawfique Hasan, Zongyin Yang, Shurong Dong, Guoqing Ding, Fan Zhang, Yanlan Yu, Jie Xia, Shengming Wang, Tianyu Zheng
article en

Abstract

Long-term implantable neural probes with dual-mode optical stimulation and simultaneous electrical recording are crucial for modulating neural loop activity in vivo. Traditional probes using "add-on" strategies often suffer from mechanical rigidity, compromised electrical performance, and insufficient biocompatibility, limiting their clinical applicability. In this study, we present a method for the direct laser writing of electrode arrays onto the curved surface of optical fibers, integrating them within a biocompatible polymer coating to create monolithic neural probes. The monolithic probes demonstrate high mechanical bending endurance, stable impedance, and improved biocompatibility, resulting in a lower inflammatory response compared to conventional systems. Furthermore, our method facilitates the multilayer integration of multilayer electrodes onto optical fibers, enabling high-density electrical readout channels. This advancement represents substantial progress in neuroengineering, with promising implications for future neural monitoring and modulation applications.

Science AdvancesVol. 11(39)
Ministry of Education (NZ), University of Cambridge (GB), Sir Run Run Shaw Hospital (CN), Interface (United States) (US), Zhejiang Provincial Institute of Communications Planning,Design & Research (CN), Zhejiang University (CN)
Openalex Percentile: Top 71%
Neuroscience and Neural Engineering
DOIOpen Access PDFOpenAlex
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