Clinical, laboratory and genetic factors associated with smoking in a Brazilian Sickle Cell Disease (SCD) cohort
Biological sex, age, and educational level are associated with smoking status among adults with SCD, and tobacco use appears to correlate with elevated hemoglobin levels in this population. Although no genome-wide significant associations were identified, our findings highlight potential genetic loci-particularly within AL110114.1 and NCOR2-that warrant further investigation in relation to smoking behavior in individuals with SCD.
Authors
- Shannon Kelly (ORCID: https://orcid.org/0000-0003-2049-3992)
- Mina Cintho Ozahata (ORCID: https://orcid.org/0000-0002-1272-2380)
- André Rolim Belisário (ORCID: https://orcid.org/0000-0003-0166-4258)
- Beatriz Araújo Oliveira
- Carla Luana Dinardo (ORCID: https://orcid.org/0000-0002-0453-7863)
- Brian Custer (ORCID: https://orcid.org/0000-0001-6251-366X)
- Frederico Leon Arrabal Fernandes (ORCID: https://orcid.org/0000-0002-3057-5716)
- Anna Bárbara de Freitas Carneiro-Proietti (ORCID: https://orcid.org/0000-0003-4302-5817)
- Sheila de Oliveira Garcia Mateos (ORCID: https://orcid.org/0000-0001-5416-2724)
- Éster Cerdeira Sabino (ORCID: https://orcid.org/0000-0003-2623-5126)
- Rodrigo Juliano Oliveira (ORCID: https://orcid.org/0000-0003-3514-3346)
- Cecília Salete Alencar (ORCID: https://orcid.org/0000-0002-3583-2275)
- Paula Loureiro (ORCID: https://orcid.org/0000-0003-1849-0047)
- Isabel Cristina Gomes (ORCID: https://orcid.org/0000-0002-5549-3426)
- Tersio G.S. Cruz
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal de Mato Grosso do Sul (BR)
- Pacific Research Institute (US)
- Hemorio (BR)
- Instituto de Medicina Tropical (PY)
- Vitalant (US)
- UCSF Benioff Children's Hospital (US)
- Fundação Hemopa (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (BR)
- Fundação Pró-Sangue Hemocentro de São Paulo (BR)
- Universidade de Pernambuco (BR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1371/journal.pone.0332305
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00