Hirsutane sesquiterpenoids from basidiomycete <i>Pseudohydropus</i> cf. <i>parafunebris</i>
Two undescribed hirsutane-type sesquiterpenes, hydropusins A (<b>1</b>) and B (<b>2</b>), along with two known hirsutanes, 6,7-epoxy-4(15)-hirsutene-5-ol (<b>3</b>) and 6,7-epoxy-4(15)-hirsutene-1,5-diol (<b>4</b>), were isolated from the basidiomycete <i>Pseudohydropus</i> cf. <i>parafunebris</i> TBRC-BCC 55386, cultivated in the presence of the epigenetic regulator nicotinamide. The absolute configuration of compound <b>1</b> was determined using the modified Mosher method. Compounds <b>1</b> and <b>3</b> showed weak cytotoxicity towards NCI-H187 cancer cells, with IC<sub>50</sub> values of 161 and 144 µM, respectively.
Authors
- Masahiko Isaka (ORCID: https://orcid.org/0000-0002-9229-3394)
- Malipan Sappan
- Thitiya Boonpratuang (ORCID: https://orcid.org/0000-0001-6942-2701)
- Maneerat Pobkwamsuk
- Taridaporn Bunyapaiboonsri (ORCID: https://orcid.org/0000-0002-1338-8636)
- Somporn Palasarn (ORCID: https://orcid.org/0000-0003-3602-8673)
- Kitlada Srichomthong
Institutions
- National Science and Technology Development Agency (TH)
- National Center for Genetic Engineering and Biotechnology (TH)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1080/14786419.2025.2565269
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00