Deciphering functional landscapes of rumen microbiota unveils the role of Prevotella bryantii in milk fat synthesis in goats
Our study establishes a causal link between rumen microbial metabolism and mammary lipid synthesis mediated by nicotinamide-mTORC1 signaling and identifies Prevotella abundance as a biomarker for precision breeding. These findings advance the understanding of microbiome-host crosstalk in lactation and provide actionable strategies for enhancing dairy productivity through microbiota-targeted interventions.
Authors
- Lu Deng (ORCID: https://orcid.org/0000-0001-6932-4597)
- Yining Zheng
- Yiting Yan
- Xi Cao (ORCID: https://orcid.org/0000-0001-5447-6766)
- Qiang Qiu (ORCID: https://orcid.org/0000-0002-9874-271X)
- Kai Zhang (ORCID: https://orcid.org/0000-0003-2800-0531)
- Zhipeng Li (ORCID: https://orcid.org/0000-0001-8474-045X)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-2392-1545)
- Yulin Chen (ORCID: https://orcid.org/0000-0001-8514-0309)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0002-3987-6638)
- Ting Zhang (ORCID: https://orcid.org/0000-0003-4229-6332)
- Shiwei Chen (ORCID: https://orcid.org/0000-0002-4766-6980)
- Lei Yu (ORCID: https://orcid.org/0000-0001-7246-8305)
- Xuyang Sun
- Xiumin Zhang (ORCID: https://orcid.org/0000-0002-3906-1180)
- Bo Yang (ORCID: https://orcid.org/0009-0002-2901-760X)
- Jinping Shi (ORCID: https://orcid.org/0000-0002-4914-2072)
- Zhizhong Meng
- Xiaoting Yan (ORCID: https://orcid.org/0000-0002-7114-3223)
- Yangbin Xu (ORCID: https://orcid.org/0000-0002-2845-2039)
- Lan Ge
Institutions
- Gansu Agricultural University (CN)
- Northwestern Polytechnical University (CN)
- Chinese Academy of Sciences (CN)
- Hainan University (CN)
- Longdong University (CN)
- North West Agriculture and Forestry University (CN)
- Institute of Subtropical Agriculture (CN)
- Sanya University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Jilin Agricultural University (CN)
- Ministry of Agriculture (TN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13059-025-03788-z
- Citations
- 5
- Primary Topic
- Ruminant Nutrition and Digestive Physiology
- Type
- article
- Field-Weighted Citation Impact
- 9.51
Funders
- Northwestern University
- National Natural Science Foundation of China
- Northwestern Polytechnical University
- Northwest A and F University
- China Agricultural Research System
- National Key Research and Development Program of China
- Key Research and Development Projects of Shaanxi Province