Clinical Outcomes of Cardiac Implantable Electronic Device-Related Endocarditis: An International ID-IRI Study

<b>Background/Objectives:</b> Cardiac implantable electronic device-related infective endocarditis (CIED-RIE) is a serious condition with significant morbidity and mortality. Although recent advances in imaging and therapeutic approaches have improved management, diagnosing and treating CIED-RIE continues to be challenging. This study aimed to identify factors associated with mortality in CIED-RIE patients. <b>Methods:</b> We conducted a retrospective, multicenter international study of adult patients diagnosed with CIED-RIE between January 2014 and June 2024. Data on demographics, clinical presentation, microbiological findings, imaging results, treatment modalities, and outcomes were collected and analyzed to determine predictors of short-term mortality. <b>Results:</b> A total of 197 patients (mean age: 65.3 ± 14.4 years; 75.1% male) were included. The most common device type was permanent pacemaker (48.2%). Staphylococcus species were the predominant pathogens (62.4%). Surgical intervention was performed in 67.5% of patients, and 90-day mortality occurred in 19.3%. Multivariable analysis identified higher Charlson comorbidity index (HR: 1.31), tricuspid valve involvement (HR: 2.35), vegetation size ≥ 10 mm (HR: 2.53), pulmonary embolism (HR: 3.92), and absence of surgical intervention (HR: 2.90) as independent predictors of increased 90-day mortality. <b>Conclusions:</b> Early identification of high-risk patients and prompt multidisciplinary management, including surgical intervention when indicated, are critical to improving outcomes in patients with CIED-RIE.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Medicine
Published
2025-09-26
DOI
https://doi.org/10.3390/jcm14196816
Primary Topic
Infective Endocarditis Diagnosis and Management
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Clinical Outcomes of Cardiac Implantable Electronic Device-Related Endocarditis: An International ID-IRI Study

Oktay Musayev, Mehmet Emin Bilgin, Fahad Almajid, Selda Aydın et al.
Journal of Clinical Medicine
Infective Endocarditis Diagnosis and Management
article

Clinical Outcomes of Cardiac Implantable Electronic Device-Related Endocarditis: An International ID-IRI Study

Oktay Musayev, Mehmet Emin Bilgin, Fahad Almajid, Selda Aydın, Oğuzhan Acet, Juan Pablo Escalera-Antezana, Mehmet Ali Tüz, Edmond Puca, Fethi Kılıçarslan, Özay Akyıldız, Fahrettin Katkat, Muhammed Heja Geçit, Ivica Markota, Sevil Alkan, Oğuz Reşat Sıpahı, Botond Lakatos, Bálint Gergely Szabó, Zübeyir Bulat, Antonio Cascio, Mehmet Emin Gökçe, Hagar Lotfy Mowafy, Serkan Öncü, Şükrü Arslan, Tarsila Vieceli, Firdevs Aksoy, Amani El‐Kholy, Lorenza Guella, Hakan Erdem, Mustafa Yıldız, A.U. Pekok, Javier Crespo, Gülay Okay, Ahmet Naci Emecen, Bilal Ahmad Rahimi, Ali Mert, Selçuk Kaya, Samir Javadli
article en

Abstract

<b>Background/Objectives:</b> Cardiac implantable electronic device-related infective endocarditis (CIED-RIE) is a serious condition with significant morbidity and mortality. Although recent advances in imaging and therapeutic approaches have improved management, diagnosing and treating CIED-RIE continues to be challenging. This study aimed to identify factors associated with mortality in CIED-RIE patients. <b>Methods:</b> We conducted a retrospective, multicenter international study of adult patients diagnosed with CIED-RIE between January 2014 and June 2024. Data on demographics, clinical presentation, microbiological findings, imaging results, treatment modalities, and outcomes were collected and analyzed to determine predictors of short-term mortality. <b>Results:</b> A total of 197 patients (mean age: 65.3 ± 14.4 years; 75.1% male) were included. The most common device type was permanent pacemaker (48.2%). Staphylococcus species were the predominant pathogens (62.4%). Surgical intervention was performed in 67.5% of patients, and 90-day mortality occurred in 19.3%. Multivariable analysis identified higher Charlson comorbidity index (HR: 1.31), tricuspid valve involvement (HR: 2.35), vegetation size ≥ 10 mm (HR: 2.53), pulmonary embolism (HR: 3.92), and absence of surgical intervention (HR: 2.90) as independent predictors of increased 90-day mortality. <b>Conclusions:</b> Early identification of high-risk patients and prompt multidisciplinary management, including surgical intervention when indicated, are critical to improving outcomes in patients with CIED-RIE.

Journal of Clinical MedicineVol. 14(19)
Balıkesir University (TR), Çanakkale Onsekiz Mart Üniversitesi (TR), Cairo University (EG), Karadeniz Technical University (TR), Azerbaijan Medical University (AZ), Dokuz Eylül University (TR), Şırnak University (TR), University Clinical Hospital Mostar (BA), Mother Teresa Hospital (AL), Santa Casa Hospital (BR), King Saud University (SA), Bezmiâlem Vakıf Üniversitesi (TR), Istanbul Medipol University (TR), Kandahar University (AF), Universidad Mayor de San Simón (BO), Ege University (TR), Ospedale Santa Chiara (IT), Gülhane Askerî Tıp Akademisi (TR), Istanbul University-Cerrahpaşa (TR), Fundación PROINPA (BO), Sağlık Bilimleri Üniversitesi (TR), Istanbul Eye Hospital (TR), Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT), Istanbul University (TR), Adnan Menderes University (TR), University of Health Sciences Antigua (AG), University of Palermo (IT)
Openalex Percentile: Top 64%
Infective Endocarditis Diagnosis and Management
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.