Chromatin landscape, transcriptomic and ChIP-seq profiling of Anopheles stephensi MSQ43 cell line

Anopheles mosquitoes are known as dominant vectors of malaria parasites and other viral and bacterial pathogens. Deciphering Anopheles genomes has opened a new era of research and allowed in-depth investigation of several molecular mechanisms involved in pathogen transmission. However, there is a lack of appropriate model systems to study specific vector-pathogen interactions at the molecular level. Even inbred mosquito colonies represent genetically heterogeneous population and require special care facilities. Insect cell cultures could serve as a useful alternative due to the ease of handling and maintenance, especially for genomic studies requiring millions of cells per experiment. Here, we provide chromatin contact maps and a dataset of epigenetic characteristics, including histone mark profiles and RNA-seq data, as well as transfection conditions and promoter specificity for the mosquito cell line MSQ43.

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Publication Details

Journal
Scientific Data
Published
2025-09-26
DOI
https://doi.org/10.1038/s41597-025-05721-2
Primary Topic
Insect Resistance and Genetics
Type
article
Field-Weighted Citation Impact
0.00

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article

Chromatin landscape, transcriptomic and ChIP-seq profiling of Anopheles stephensi MSQ43 cell line

Andrey Popov, Anna Khabarova, Maria Gridina, Varvara Lukyanchikova et al.
Scientific Data
Insect Resistance and Genetics
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Chromatin landscape, transcriptomic and ChIP-seq profiling of Anopheles stephensi MSQ43 cell line

Andrey Popov, Anna Khabarova, Maria Gridina, Varvara Lukyanchikova, Miroslav Nuriddinov, Veniamin Fishman, Polina Belokopytova, Igor V. Sharakhov
article en

Abstract

Anopheles mosquitoes are known as dominant vectors of malaria parasites and other viral and bacterial pathogens. Deciphering Anopheles genomes has opened a new era of research and allowed in-depth investigation of several molecular mechanisms involved in pathogen transmission. However, there is a lack of appropriate model systems to study specific vector-pathogen interactions at the molecular level. Even inbred mosquito colonies represent genetically heterogeneous population and require special care facilities. Insect cell cultures could serve as a useful alternative due to the ease of handling and maintenance, especially for genomic studies requiring millions of cells per experiment. Here, we provide chromatin contact maps and a dataset of epigenetic characteristics, including histone mark profiles and RNA-seq data, as well as transfection conditions and promoter specificity for the mosquito cell line MSQ43.

Scientific DataVol. 12(1)
Skolkovo Institute of Science and Technology (RU), Novosibirsk State University (RU), National Research Tomsk State University (RU), Sirius University of Science and Technology (RU), Institute of Cytology and Genetics (RU), Siberian Branch of the Russian Academy of Sciences (RU), Yandex (Russia) (RU), Virginia Tech (US)
Siberian Branch, Russian Academy of Sciences, Ministry of Science and Higher Education of the Russian Federation, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Openalex Percentile: Top 77%
Insect Resistance and Genetics
DOIOpen Access PDFOpenAlex
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